Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.

نویسندگان

  • Wolfgang Kandioller
  • Evelyn Balsano
  • Samuel M Meier
  • Ute Jungwirth
  • Simone Göschl
  • Alexander Roller
  • Michael A Jakupec
  • Walter Berger
  • Bernhard K Keppler
  • Christian G Hartinger
چکیده

Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

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عنوان ژورنال:
  • Chemical communications

دوره 49 32  شماره 

صفحات  -

تاریخ انتشار 2013